Microbiological screening of compounds with potential anti-lep activity among new synthesis compounds of the pyrimidine series

Aim: To study the effect of new synthesized pyrimidine derivatives on growth Mycobacterium lufu ( M. ) and tuberculosis when cultivated Shkolnikova’s medium. Materials methods. The objects research were 6 samples - 5-(arylmethylidene)-2,4,6-pyrimidine-2,4,6(1 H ,3 ,5 )-trions under laboratory codes TAG1, TAG2, TAG3, TAG4, TAG5, TAG6 7 5-(getarylmethylidene)-2,4,6-pyrimidine-2,4,6(1 , 3 5 TAG7, TAG8, TAG9, TAG10, TAG11, TAG12, TAG13. tuberculosisH37Rv strains used as test cultures. antimycobacterial activity studied compounds was by method serial dilutions. Research results. All found to exhibit activity. greatest inhibitory against noted for TAG13, which comparable that reference drug dapsone. By nature TAG 1, 4, TAG13 isoniazid, TAG3 compound even slightly superior drug. Conclusion. Among derivatives, have most pronounced antimicrobial both allows us consider them promising substances further search antimycobacterial, including antileprosy drugs.